William Howard Stein

American biochemist (1911–1980)

  • Fame51.4
  • Momentum0.0
  • Wikipedia616
Source-basedFalling
Lived 1911–1980, aged 69United States
  • Wikipedia
    53 languages
    Cross-language footprint
  • Era
    1911–1980
    Aged 69
  • Awards
    1
    recognised work
Summary
Updated 2026-06-09

He cracked the code of how enzymes work at the molecular level — mapping ribonuclease atom by atom and proving that a protein's shape dictates its chemical power.

Biography

About

William Howard Stein was born June 25, 1911, and spent his career unraveling the mechanics inside living cells. Working with collaborators, he determined the complete sequence of ribonuclease, an enzyme that breaks down RNA, then traced how its three-dimensional structure enables its catalytic function. That work earned him the Nobel Prize in Chemistry in 1972. Along the way, Stein helped invent the automatic amino acid analyzer, a machine that automated the tedious process of identifying amino acids in proteins and effectively birthed modern chromatography techniques — liquid, gas, the whole…

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Fame
Falling
51.4
Composite of search demand, mentions, audience & graph footprint.
Score components
Historical22.0
Source confidence60.0
Completeness70.0
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Sources

  • Wikipedia
    wikipedia · en.wikipedia.org
    High confidence
  • Wikidata
    wikidata · wikidata.org
    High confidence
  • Pantheon 2.0
    database · pantheon.world
    High confidence