Jerome Karle
American physical chemist (1918-2013) · United States · Scientists · Died at 94
Jerome Karle is read about 22 times a day, in 56 languages.
A typical day, 30 days to 17 September 2026
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Something wrong?He cracked the atomic geometry of crystals without needing to build models first - a mathematical leap that let scientists see the architecture of matter directly from X-ray scatter, work that earned him a Nobel in 1985.
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Photos 8
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Jerome Karle Portrait (cropped)
Jerome Karle Portrait
Jerome Karle
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Karle Retirement
Navy Distinguished Civilian Service Award 090721-N-PO203-028_the_Honorable_Ray_Mabus_gives_his_remarks_at_Drs._Jerome_and_Isabella_Karle's_retirement_ceremony_from_the_Naval_Research_Laboratory.jpg?width=1200)
US Navy 090721-N-7676W-052 The Secretary of the Navy (SECNAV) the Honorable Ray Mabus gives his remarks at Drs. Jerome and Isabella Karle's retirement ceremony from the Naval Research LaboratoryAwards
In their orbit
Spouse: Isabella KarleAbout this person
Jerome Karle was born Jerome Karfunkle on June 18, 1918. A physical chemist by training, he spent years developing methods to solve one of chemistry's hardest puzzles: determining the three-dimensional arrangement of atoms in a crystal from diffraction patterns alone. Working alongside Herbert A. Hauptman, Karle devised direct mathematical techniques that bypassed the trial-and-error guesswork that had dominated the field. The Nobel Prize in Chemistry came in 1985, recognizing a breakthrough that opened the door to rapid structure determination across biology, materials science, and drug design. He died on June 6, 2013, a week shy of his ninety-fifth birthday.
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