Jerome Karle
American physical chemist (1918–2013)
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He cracked the atomic geometry of crystals without needing to build models first — a mathematical leap that let scientists see the architecture of matter directly from X-ray scatter, work that earned him a Nobel in 1985.
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Jerome Karle was born Jerome Karfunkle on June 18, 1918. A physical chemist by training, he spent years developing methods to solve one of chemistry's hardest puzzles: determining the three-dimensional arrangement of atoms in a crystal from diffraction patterns alone. Working alongside Herbert A. Hauptman, Karle devised direct mathematical techniques that bypassed the trial-and-error guesswork that had dominated the field. The Nobel Prize in Chemistry came in 1985, recognizing a breakthrough that opened the door to rapid structure determination across biology, materials science, and drug desig…
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