Cleopatra of Macedon

Born around 355 BC, she was the daughter of Philip II of Macedon and Olympias of Epirus — the sole full sibling in a family of half-brothers and half-sisters vying for pieces of her father's kingdom. While her brother marched east and rewrote the map, she held power in Epirus as queen regent, a rare position for a woman in the Macedonian world. She survived the wars of succession that tore through the family after Alexander died, outlasting some siblings but not all. She was killed in 308 BC, forty-seven years into a life spent in the long shadow of the greatest conqueror in history.