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Ralph L. Brinster

American geneticist · United States · On the map · Academics · Born 1932 · age 94

Ralph Lawrence Brinster is an American geneticist, National Medal of Science laureate, and Richard King Mellon Professor of Reproductive Physiology at the School of Veterinary Medicine, University of Pennsylvania.

Ralph L. Brinster is read about 9 times a day, in 8 languages.

A typical day, 30 days to 21 June 2026

The middle day of the days counted, so one week of news cannot move it. The line under it is the last 60 days, one point a day.

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A life in dates

2010National Medal of ScienceAward2006Canada Gairdner International AwardAward2002Wolf Prize in MedicineAward1997Bower Award and Prize for Achievement in ScienceAwardJohn Scott AwardAward1996March of Dimes Prize in Developmental BiologyAward1994Grand Prix Charles-Leopold MayerAward1932Born10 March 1932

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Fig. 1. Mouse egg culture. The image shows the dish in which embryos are cultured and the progression of two-cell embryos to a hollow structure known as the blastocyst.[9]Fig. 1. Mouse egg culture. The image shows the dish in which embryos are cultured and the progression of two-cell embryos to a hollow structure known as the blastocyst.[9]Fig. 2. Chimeric mouse. This mouse resulted from a blastocyst, which normally would produce a white mouse, that was injected with teratocarcinoma cells from a brown mouse. The dark stripes on the mouse represent the contribution of the foreign brown-type cells.[11]Fig. 2. Chimeric mouse. This mouse resulted from a blastocyst, which normally would produce a white mouse, that was injected with teratocarcinoma cells from a brown mouse. The dark stripes on the mouse represent the contribution of the foreign brown-type cells.[11]Fig. 4. Giant/Super Mouse produced from growth hormone gene injection into mouse egg. The small mouse is of normal size, and the large mouse resulted from a fertilized egg injected with a growth hormone gene, as shown in figure 3 above. The injected egg was transferred to a foster mother uterus and subsequently produced the large mouse which grew twice as fast and became 50% larger.[12]Fig. 4. Giant/Super Mouse produced from growth hormone gene injection into mouse egg. The small mouse is of normal size, and the large mouse resulted from a fertilized egg injected with a growth hormone gene, as shown in figure 3 above. The injected egg was transferred to a foster mother uterus and subsequently produced the large mouse which grew twice as fast and became 50% larger.[12]Fig. 3. New gene being injected into fertilized mouse egg. The top image is a fertilized mouse egg before injection, and the bottom image is the egg following introduction of a solution containing a new gene (note the swollen pro-nuclear structure in the lower egg, which contains the chromosomes of the egg and the new gene).[13]Fig. 3. New gene being injected into fertilized mouse egg. The top image is a fertilized mouse egg before injection, and the bottom image is the egg following introduction of a solution containing a new gene (note the swollen pro-nuclear structure in the lower egg, which contains the chromosomes of the egg and the new gene).[13]Fig. 5. Top panel. Recipient mouse testis that was injected with genetically modified spermatogonial stem cells containing a reporter transgene for Green Fluorescent Protein (GFP), which will fluoresce green. Bottom Panel. The testis will produce spermatozoa that transmitted the GFP transgene to offspring.[20]Fig. 5. Top panel. Recipient mouse testis that was injected with genetically modified spermatogonial stem cells containing a reporter transgene for Green Fluorescent Protein (GFP), which will fluoresce green. Bottom Panel. The testis will produce spermatozoa that transmitted the GFP transgene to offspring.[20]Fig. 6. Male germline stem cell transplantation. The proposed clinical application of human spermatogonial stem cells (SSCs). Before treatment for cancer by chemotherapy or irradiation, a prepubertal boy could undergo a testicular biopsy to recover SSCs. The SSCs would be cryopreserved and/or cultured to expand their number in vitro. After treatment, the SSCs would be transplanted to the patient's testes to produce spermatozoa. A step for genetic correction to rescue a genetic disorder is possible prior to transplantation.[21]Fig. 6. Male germline stem cell transplantation. The proposed clinical application of human spermatogonial stem cells (SSCs). Before treatment for cancer by chemotherapy or irradiation, a prepubertal boy could undergo a testicular biopsy to recover SSCs. The SSCs would be cryopreserved and/or cultured to expand their number in vitro. After treatment, the SSCs would be transplanted to the patient's testes to produce spermatozoa. A step for genetic correction to rescue a genetic disorder is possible prior to transplantation.[21]Professor Ralph Brinster receiving the National Medal of Science from President Barack Obama.Professor Ralph Brinster receiving the National Medal of Science from President Barack Obama.

Awards

National Medal of Science2010
Canada Gairdner International Award2006
Wolf Prize in Medicine2002
Bower Award and Prize for Achievement in Science1997
John Scott Award1997
March of Dimes Prize in Developmental Biology1996
Grand Prix Charles-Leopold Mayer1994
Fellow of the American Academy of Arts and Sciences

About this person

Country
United States
Category
Academics
Type
Academic
Status
Living
Dates
Born 1932 · age 94

Academics from the United States 6

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