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Ralph L. Brinster

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American geneticist

United StatesAcademicsBorn 1932 · age 94
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Ralph Lawrence Brinster is an American geneticist, National Medal of Science laureate, and Richard King Mellon Professor of Reproductive Physiology at the School of Veterinary Medicine, University of Pennsylvania.

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Photos 9

Fig. 1. Mouse egg culture. The image shows the dish in which embryos are cultured and the progression of two-cell embryos to a hollow structure known as the blastocyst.[9]Fig. 1. Mouse egg culture. The image shows the dish in which embryos are cultured and the progression of two-cell embryos to a hollow structure known as the blastocyst.[9]Fig. 2. Chimeric mouse. This mouse resulted from a blastocyst, which normally would produce a white mouse, that was injected with teratocarcinoma cells from a brown mouse. The dark stripes on the mouse represent the contribution of the foreign brown-type cells.[11]Fig. 2. Chimeric mouse. This mouse resulted from a blastocyst, which normally would produce a white mouse, that was injected with teratocarcinoma cells from a brown mouse. The dark stripes on the mouse represent the contribution of the foreign brown-type cells.[11]Fig. 4. Giant/Super Mouse produced from growth hormone gene injection into mouse egg. The small mouse is of normal size, and the large mouse resulted from a fertilized egg injected with a growth hormone gene, as shown in figure 3 above. The injected egg was transferred to a foster mother uterus and subsequently produced the large mouse which grew twice as fast and became 50% larger.[12]Fig. 4. Giant/Super Mouse produced from growth hormone gene injection into mouse egg. The small mouse is of normal size, and the large mouse resulted from a fertilized egg injected with a growth hormone gene, as shown in figure 3 above. The injected egg was transferred to a foster mother uterus and subsequently produced the large mouse which grew twice as fast and became 50% larger.[12]Fig. 3. New gene being injected into fertilized mouse egg. The top image is a fertilized mouse egg before injection, and the bottom image is the egg following introduction of a solution containing a new gene (note the swollen pro-nuclear structure in the lower egg, which contains the chromosomes of the egg and the new gene).[13]Fig. 3. New gene being injected into fertilized mouse egg. The top image is a fertilized mouse egg before injection, and the bottom image is the egg following introduction of a solution containing a new gene (note the swollen pro-nuclear structure in the lower egg, which contains the chromosomes of the egg and the new gene).[13]Fig. 5. Top panel. Recipient mouse testis that was injected with genetically modified spermatogonial stem cells containing a reporter transgene for Green Fluorescent Protein (GFP), which will fluoresce green. Bottom Panel. The testis will produce spermatozoa that transmitted the GFP transgene to offspring.[20]Fig. 5. Top panel. Recipient mouse testis that was injected with genetically modified spermatogonial stem cells containing a reporter transgene for Green Fluorescent Protein (GFP), which will fluoresce green. Bottom Panel. The testis will produce spermatozoa that transmitted the GFP transgene to offspring.[20]Fig. 6. Male germline stem cell transplantation. The proposed clinical application of human spermatogonial stem cells (SSCs). Before treatment for cancer by chemotherapy or irradiation, a prepubertal boy could undergo a testicular biopsy to recover SSCs. The SSCs would be cryopreserved and/or cultured to expand their number in vitro. After treatment, the SSCs would be transplanted to the patient's testes to produce spermatozoa. A step for genetic correction to rescue a genetic disorder is possible prior to transplantation.[21]Fig. 6. Male germline stem cell transplantation. The proposed clinical application of human spermatogonial stem cells (SSCs). Before treatment for cancer by chemotherapy or irradiation, a prepubertal boy could undergo a testicular biopsy to recover SSCs. The SSCs would be cryopreserved and/or cultured to expand their number in vitro. After treatment, the SSCs would be transplanted to the patient's testes to produce spermatozoa. A step for genetic correction to rescue a genetic disorder is possible prior to transplantation.[21]Professor Ralph Brinster receiving the National Medal of Science from President Barack Obama.Professor Ralph Brinster receiving the National Medal of Science from President Barack Obama.

Awards 8

2010National Medal of Science
2006Canada Gairdner International Award
2002Wolf Prize in Medicine
1997Bower Award and Prize for Achievement in Science
1997John Scott Award
1996March of Dimes Prize in Developmental Biology
1994Grand Prix Charles-Leopold Mayer
Fellow of the American Academy of Arts and Sciences

Connected to Ralph 6

Walter J. GehringAlso won March of Dimes Prize in Developmental BiologyJohn W. CahnAlso won Bower Award and Prize for Achievement in ScienceMeir WilchekAlso won Wolf Prize in MedicineCharles L. KaneAlso won John Scott AwardPiotr SłonimskiAlso won Grand Prix Charles-Leopold MayerErnest William GoodpastureAlso won John Scott Award

About this person

Country
United States
Category
Academics
Type
Academic
Status
living
Dates
Born 1932 · age 94
Written about in
8 languages

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