Pompeo Colonna

Born in Rome, he was the son of Girolamo Colonna, whose father Antonio was second Prince of Salerno; and Vittoria Conti, of the Conti de Poli. His family belonged to the highest rank of nobility both of the City of Rome and of the Kingdom of Naples. Pompeo and his family were hereditary supporters of the Holy Roman Empire (Ghibbelines), and they spent their careers fighting their hereditary enemies, the Orsini family, and defending and expanding their family territories and interests. He played a significant, if sometimes disruptive, role in the Conclaves of 1521 and 1523 on behalf of the Imperial interest. His family commitments and his conclave activities brought Pompeo into conflict with the second Medici pope, Clement VII, whose election he vigorously opposed, and made him a leading figure in the attempted overthrow of Pope Clement and the Sack of Rome in 1527.