Holden G. Karnofsky is an American nonprofit executive. Karnofsky co-founded the charity evaluator GiveWell with Elie Hassenfeld in 2007. He co-founded in 2014 the grantmaking organization Open Philanthropy, and was its CEO and later co-CEO until 2023. He joined Anthropic in 2025.
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In their own words 5
I think it's somewhat of a happy coincidence so far that most breakthroughs have been good. To say, I see a breakthrough on the horizon. Is that good or bad?
In an interview with Robert Wiblin, February 2018; also quoted by Ben Pace in "Extended Quote on the Institution of Academia" and by Rob
I model the world as having most of the impact from extreme cases, 'home-runs'. I think that's true in business, science and social impact.
In an interview with Benjamin Todd, January 2014
I could tell you about my strengths and weaknesses.
In an interview with Benjamin Todd, January 2014
In their orbit 1
About this person
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