# William Howard Stein

> He cracked the code of how enzymes work at the molecular level - mapping ribonuclease atom by atom and proving that a protein's shape dictates its chemical power.

*American biochemist (1911-1980)*

**Canonical URL:** https://fame.am/person/william-howard-stein

## Identity
- **Profile type:** Scientist ([Wikidata](https://www.wikidata.org/entity/Q39631))
- **Category:** Scientists
- **Country:** United States
- **Born:** 1911-06-25
- **Died:** 1980-02-02
- **Status:** deceased
- **Gender:** male

## Bio

William Howard Stein was born June 25, 1911, and spent his career unraveling the mechanics inside living cells. Working with collaborators, he determined the complete sequence of ribonuclease, an enzyme that breaks down RNA, then traced how its three-dimensional structure enables its catalytic function. That work earned him the Nobel Prize in Chemistry in 1972. Along the way, Stein helped invent the automatic amino acid analyzer, a machine that automated the tedious process of identifying amino acids in proteins and effectively birthed modern chromatography techniques - liquid, gas, the whole lineage. He died February 2, 1980, having shown that you could read a protein like a sentence and understand why it does what it does.

## Fame
- **Popularity score:** 55.7 / 100
- **Momentum:** 13.8 / 100  (trend: BREAKOUT)
- **Historical depth:** 24.0 / 100
- **Attention shift:** 66.9 / 100
- **Source confidence:** 60.0 / 100
- **Profile completeness:** 70.0 / 100

## Topics
#Scientists, #Chemistry, #United States, #Americas, #20th Century

## Sources
- [William Howard Stein](https://pt.wikipedia.org/wiki/William_Howard_Stein)
- [William Stein](https://nl.wikipedia.org/wiki/William_Stein)
- [William Stein](https://it.wikipedia.org/wiki/William_Stein)
- [威廉·霍华德·斯坦](https://zh.wikipedia.org/wiki/%E5%A8%81%E5%BB%89%C2%B7%E9%9C%8D%E5%8D%8E%E5%BE%B7%C2%B7%E6%96%AF%E5%9D%A6)
- [ウィリアム・スタイン](https://ja.wikipedia.org/wiki/%E3%82%A6%E3%82%A3%E3%83%AA%E3%82%A2%E3%83%A0%E3%83%BB%E3%82%B9%E3%82%BF%E3%82%A4%E3%83%B3)
- [Стайн, Уильям Говард](https://ru.wikipedia.org/wiki/%D0%A1%D1%82%D0%B0%D0%B9%D0%BD%2C_%D0%A3%D0%B8%D0%BB%D1%8C%D1%8F%D0%BC_%D0%93%D0%BE%D0%B2%D0%B0%D1%80%D0%B4)
- [William Howard Stein](https://pl.wikipedia.org/wiki/William_Howard_Stein)
- [Wikidata](https://www.wikidata.org/wiki/Q156492)
- [Wikipedia](https://en.wikipedia.org/wiki/William_Howard_Stein)
- [Pantheon 2.0](https://pantheon.world/profile/person/William%20Howard%20Stein)
- [William Howard Stein](https://ca.wikipedia.org/wiki/William_Howard_Stein)
- [William Howard Stein](https://cs.wikipedia.org/wiki/William_Howard_Stein)
- [William Howard Stein](https://da.wikipedia.org/wiki/William_Howard_Stein)
- [William Howard Stein](https://de.wikipedia.org/wiki/William_Howard_Stein)
- [William Howard Stein](https://es.wikipedia.org/wiki/William_Howard_Stein)
- [William Howard Stein](https://eu.wikipedia.org/wiki/William_Howard_Stein)
- [ویلیام اشتین](https://fa.wikipedia.org/wiki/%D9%88%DB%8C%D9%84%DB%8C%D8%A7%D9%85_%D8%A7%D8%B4%D8%AA%DB%8C%D9%86)
- [William Howard Stein](https://fi.wikipedia.org/wiki/William_Howard_Stein)
- [William Howard Stein](https://fr.wikipedia.org/wiki/William_Howard_Stein)
- [William Howard Stein](https://ga.wikipedia.org/wiki/William_Howard_Stein)
- [William H. Stein](https://gd.wikipedia.org/wiki/William_H._Stein)
- [William Howard Stein](https://gl.wikipedia.org/wiki/William_Howard_Stein)
- [William Howard Stein](https://hak.wikipedia.org/wiki/William_Howard_Stein)
- [ויליאם סטיין](https://he.wikipedia.org/wiki/%D7%95%D7%99%D7%9C%D7%99%D7%90%D7%9D_%D7%A1%D7%98%D7%99%D7%99%D7%9F)
- [William H. Stein](https://hu.wikipedia.org/wiki/William_H._Stein)
- [William H. Stein](https://id.wikipedia.org/wiki/William_H._Stein)
- [William Howard Stein](https://io.wikipedia.org/wiki/William_Howard_Stein)
- [উইলিয়াম এইচ. স্টেইন](https://bn.wikipedia.org/wiki/%E0%A6%89%E0%A6%87%E0%A6%B2%E0%A6%BF%E0%A6%AF%E0%A6%BC%E0%A6%BE%E0%A6%AE_%E0%A6%8F%E0%A6%87%E0%A6%9A._%E0%A6%B8%E0%A7%8D%E0%A6%9F%E0%A7%87%E0%A6%87%E0%A6%A8)
- [Уилям Стайн](https://bg.wikipedia.org/wiki/%D0%A3%D0%B8%D0%BB%D1%8F%D0%BC_%D0%A1%D1%82%D0%B0%D0%B9%D0%BD)
- [Уільям Хоўвард Стайн](https://be.wikipedia.org/wiki/%D0%A3%D1%96%D0%BB%D1%8C%D1%8F%D0%BC_%D0%A5%D0%BE%D1%9E%D0%B2%D0%B0%D1%80%D0%B4_%D0%A1%D1%82%D0%B0%D0%B9%D0%BD)

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