# Fame.am profile — machine-readable export
# Canonical URL: https://fame.am/person/margaret-oakley-dayhoff
# Generated: 2026-08-14T23:02:52.537Z

schema: https://schema.org/Person
url: "https://fame.am/person/margaret-oakley-dayhoff"
name: "Margaret Oakley Dayhoff"
slug: "margaret-oakley-dayhoff"
description: "Margaret Belle (Oakley) Dayhoff was an American biophysicist and a pioneer in the field of bioinformatics. Dayhoff was a professor at Georgetown University Medical Center and a noted research biochemist at the National Biomedical Research Foundation, where she pioneered the application of mathematics and computational methods to the field of biochemistry. She dedicated her career to applying the evolving computational technologies to support advances in biology and medicine, most notably the creation of protein and nucleic acid databases and tools to interrogate the databases. She originated one of the first substitution matrices, point accepted mutations (PAM). The one-letter code used for amino acids was developed by her, reflecting an attempt to reduce the size of the data files used to describe amino acid sequences in an era of punch-card computing."
tagline: "American biochemist (1925-1983)"
image: "https://upload.wikimedia.org/wikipedia/en/e/e5/Photo_of_Margaret_Oakley_Dayhoff.jpg"
gender: "female"
country:
  name: "United States"
  isoCode: "US"
category:
  name: "Scientists"
  slug: "scientists"
profileType:
  name: "Scientist"
  slug: "scientist"
  entityType: "https://www.wikidata.org/entity/Q39631"
birthDate: "1925-03-11"
deathDate: "1983-02-05"
livingStatus: "DECEASED"
scores:
  popularity:           48.16
  momentum:             0.2913752913752913
  historical:           15.09845466666667
  currentAttention:     0
  sourceConfidence:     60
  profileCompleteness:  70
  trendDirection:       "FALLING"
ranks:
  global:   null
  country:  null
  category: null
sources:
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    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
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    title: "مارغريت أوكلي دايهوف"
    type:  "WIKIPEDIA"
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    title: "مارجريت اوكلى دايهوف"
    type:  "WIKIPEDIA"
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    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
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    title: "مارقارت دایهوف"
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    title: "মারগারেট ওকলি ডেহফ"
    type:  "WIKIPEDIA"
  - url: "https://ca.wikipedia.org/wiki/Margaret_Oakley_Dayhoff"
    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
  - url: "https://cy.wikipedia.org/wiki/Margaret_Oakley_Dayhoff"
    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
  - url: "https://de.wikipedia.org/wiki/Margaret_Oakley_Dayhoff"
    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
  - url: "https://en.wikipedia.org/wiki/Margaret_Oakley_Dayhoff"
    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
  - url: "https://es.wikipedia.org/wiki/Margaret_Oakley_Dayhoff"
    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
  - url: "https://fa.wikipedia.org/wiki/%D9%85%D8%A7%D8%B1%DA%AF%D8%A7%D8%B1%D8%AA_%D8%AF%D8%A7%DB%8C%D9%87%D9%88%D9%81"
    title: "مارگارت دایهوف"
    type:  "WIKIPEDIA"
  - url: "https://fr.wikipedia.org/wiki/Margaret_Oakley_Dayhoff"
    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
  - url: "https://it.wikipedia.org/wiki/Margaret_Dayhoff"
    title: "Margaret Dayhoff"
    type:  "WIKIPEDIA"
  - url: "https://ja.wikipedia.org/wiki/%E3%83%9E%E3%83%BC%E3%82%AC%E3%83%AC%E3%83%83%E3%83%88%E3%83%BB%E3%83%87%E3%82%A4%E3%83%9B%E3%83%95"
    title: "マーガレット・デイホフ"
    type:  "WIKIPEDIA"
  - url: "https://pl.wikipedia.org/wiki/Margaret_Oakley_Dayhoff"
    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
  - url: "https://pt.wikipedia.org/wiki/Margaret_Oakley_Dayhoff"
    title: "Margaret Oakley Dayhoff"
    type:  "WIKIPEDIA"
  - url: "https://ru.wikipedia.org/wiki/%D0%94%D0%B5%D0%B9%D1%85%D0%BE%D1%84%D1%84%2C_%D0%9C%D0%B0%D1%80%D0%B3%D0%B0%D1%80%D0%B5%D1%82"
    title: "Дейхофф, Маргарет"
    type:  "WIKIPEDIA"
  - url: "https://www.wikidata.org/wiki/Q456920"
    title: "Wikidata"
    type:  "WIKIDATA"

# bio (long form, separated for readability)
bio: |
  Imported from discovery source: wikidata-dump