# Fame.am profile — machine-readable export
# Canonical URL: https://fame.am/person/jerome-karle
# Generated: 2026-09-07T20:51:04.235Z

schema: https://schema.org/Person
url: "https://fame.am/person/jerome-karle"
name: "Jerome Karle"
slug: "jerome-karle"
description: "He cracked the atomic geometry of crystals without needing to build models first — a mathematical leap that let scientists see the architecture of matter directly from X-ray scatter, work that earned him a Nobel in 1985."
tagline: "American physical chemist (1918–2013)"
image: "https://commons.wikimedia.org/wiki/Special:FilePath/Jerome_Karle%2C_2009.jpg"
gender: "male"
country:
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  isoCode: "US"
category:
  name: "Scientists"
  slug: "scientists"
profileType:
  name: "Scientist"
  slug: "scientist"
  entityType: "https://www.wikidata.org/entity/Q39631"
birthDate: "1918-06-18"
deathDate: "2013-06-06"
livingStatus: "DECEASED"
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  momentum:             1.658291457286432
  historical:           22.02682
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  sourceConfidence:     60
  profileCompleteness:  70
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ranks:
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  country:  null
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# bio (long form, separated for readability)
bio: |
  Jerome Karle was born Jerome Karfunkle on June 18, 1918. A physical chemist by training, he spent years developing methods to solve one of chemistry's hardest puzzles: determining the three-dimensional arrangement of atoms in a crystal from diffraction patterns alone. Working alongside Herbert A. Hauptman, Karle devised direct mathematical techniques that bypassed the trial-and-error guesswork that had dominated the field. The Nobel Prize in Chemistry came in 1985, recognizing a breakthrough that opened the door to rapid structure determination across biology, materials science, and drug design. He died on June 6, 2013, a week shy of his ninety-fifth birthday.